Research references

(Summaries on http://www.ncbi.nlm.nih.gov)

  1. Keim V, Rohr G, Stockert HG, Haberich FJ. An additional secretory protein in the rat pancreas. Digestion. 1984;29:242-9.
  2. Orelle B, Keim V, Masciotra L, Dagorn JC, Iovanna JL.Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases. J Clin Invest. 1992;90,2284-91.
  3. Iovanna JL, Keim V, Michel R, Dagorn JC. Pancreatic gene expression is altered during acute experimental pancreatitis in the rat. Am J Physiol. 1991;261:G485-9.
  4. Iovanna J, Keim V, Nordback I, Montalto G, Camarena J, Letoublon C, Levy P, Berthézène P, Dagorn JC. Serum levels of Pancreatitis Associated Protein as indicators of the course of acute pancreatitis. Multicentric Study Group on Acute Pancreatitis. Gastroenterology 1994 ;106, 728-734
  5. Piper SN, Kumle B, Maleck WH, Suttner SW, Fent MT, Boldt J. Effects of postoperative sedation with propofol and midazolam on pancreatic function assessed by pancreatitis-associated protein. Anaesthesia. 2001;56:836-40.
  6. Piper SN, Suttner SW, Maleck WH, Kumle B, Haisch G, Boldt J. Effects of sodium nitroprusside-induced controlled hypotension on pancreatic function assessed by pancreatitis-associated protein in patients undergoing radical prostatectomy. Eur J Anaesthesiol. 2002;19:609-13
  7. Nordback I, Jaakkola M, Iovanna JL, Dagorn JC. Increased serum pancreatitis associated protein (PAP) concentration after longterm alcohol consumption: further evidence for regular subclinical pancreatic damage after heavy drinking ? Gut. 1995;36:117-20
  8. Van der Pijl JW, Boonstra JG, Barthellemy S, Smets YF, Hermans J, Bruijn JA, de Fijter JW, Daha MR, Dagorn JC. Pancreatitis-associated protein: a putative marker for pancreas graft rejection. Transplantation. 1997;63:995-1003.
  9. Iovanna JL, Ferec C, Sarles J, Dagorn JC. The pancreatitis-associated protein (PAP). A new candidate for neonatal screening of cystic fibrosis.C R Acad Sci III. 1994;317:561-4.
  10. Sarles J, Barthellemy S, Ferec C, Iovanna J, Roussey M, Farriaux JP, Toutain A, Berthelot J, Maurin N, Codet JP, Berthezene P, Dagorn JC. Blood concentrations of pancreatitis associated protein in neonates: relevance to neonatal screening for cystic fibrosis. Arch Dis Child Fetal Neonatal Ed. 1999 ; 80:F118-22.
  11. Barthellemy S, Maurin N, Roussey M, Ferec C, Murolo S, Berthezene P, Iovanna JL, Dagorn JC, Sarles J. Evaluation of 47,213 infants in neonatal screening for cystic fibrosis, using pancreatitis-associated protein and immunoreactive trypsinogen assays Arch Pediatr. 2001;8:275-81.
  12. Sarles J, Berthezene P, Le Louarn C, Somma C, Perini JM, Catheline M, Mirallie S, Luzet K, Roussey M, Farriaux JP, Berthelot J, Dagorn JC. Combining immunoreactive trypsinogen and pancreatitis-associated protein assays, a method of newborn screening for cystic fibrosis that avoids DNA analysis. J Pediatr. 2005;147:302-5.
  13. Vernooij-van Langen AM, Loeber JG, Elvers B, Triepels RH, Gille JJ, Van der Ploeg CP, et al. Novel strategies in newborn screening for cystic fibrosis: a prospective controlled study. Thorax. 2012;67(4):289-295.
  14. Cornel MC, Gille JJ, Loeber JG, Vernooij-van Langen AM, Dankert-Roelse J, Bolhuis PA. Improving test properties for neonatal cystic fibrosis screening in the Netherlands before the nationwide start by May 1st 2011. J Inherit Metab Dis. 2012;35(4):635-640.
  15. Sommerburg O, Lindner M, Muckenthaler M, Kohlmueller D, Leible S, Feneberg R, et al. Initial evaluation of a biochemical cystic fibrosis newborn screening by sequential analysis of immunoreactive trypsinogen and pancreatitis-associated protein (IRT/PAP) as a strategy that does not involve DNA testing in a Northern European population. J Inherit Metab Dis. 2010;33(Suppl 2):S263-271.
  16. Krulisova V, Balascakova M, Skalicka V, Piskackova T, Holubova A, Paderova J, et al. Prospective and parallel assessments of cystic fibrosis newborn screening protocols in the Czech Republic: IRT/DNA/IRT versus IRT/PAP and IRT/PAP/DNA. Eur J Pediatr. 2012;171(8):1223-1229.
  17. Sommerburg O, Krulisova V, Hammermann J, Lindner M, Stahl M, Muckenthaler M et al. Comparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations. J Cyst Fibros. 2013.S1569-1993
  18. Nshimyumukiza L, Bois A, Daigneault P, Lands L, Laberge A-M, Fournier D, Duplantie J, Giguère Y, Gekas J, Gagné C, Rousseau F, Reinharz D, Cost effectiveness of newborn screening for cystic fibrosis: A simulation study, J Cyst Fibros (2013).
  19. Carroccio A, Iovanna JL, Iacono G, Li Pani M, Montalto G, Cavataio F, Marasa L, Barthellemy-Bialas S, Dagorn JC. Pancreatitis-associated protein in patients with celiac disease: serum levels and immunocytochemical localization in small intestine. Digestion. 1997;58:98-103.
  20. Desjeux A, Barthet M, Barthellemy S, Dagorn JC, Hastier P, Heresbach D, Bernard JP, Grimaud JC. Serum measurements of pancreatitis associated protein in active Crohn’s disease with ileal location. Gastroenterol Clin Biol. 2002;26:23-8.
  21. Gironella M, Iovanna JL, Sans M, Gil F, Penalva M, Closa D, Miquel R, Pique JM, Panes J. Anti-inflammatory effects of pancreatitis associated protein in inflammatory bowel disease. Gut. 2005;54:1244-53.
  22. Duplan L, Michel B, Boucraut J, Barthellemy S, Desplat-Jego S, Marin V, Gambarelli D, Bernard D, Berthezene P, Alescio-Lautier B, Verdier JM. Lithostathine and Pancreatitis-associated protein are involved in the very early stages of Alzheimer’s disease. Neurobiol Aging, 2001 ;22 :79-88.
  23. Montalto G, Iovanna JL, Soresi M, Dusetti N, Carroccio A, Barthellemy-Bialas S, Cartabellotta A, Dagorn JC. Clinical evaluation of pancreatitis-associated protein as a serum marker of hepatocellular carcinoma: comparison with alpha-fetoprotein. Oncology. 1998;55:421-5.
  24. Rosty C, Christa L, Kuzdzal S, Baldwin WM, Zahurak ML, Carnot F, Chan DW, Canto M, Lillemoe KD, Cameron JL, Yeo CJ, Hruban RH, Goggins M. Identification of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein I as a biomarker for pancreatic ductal adenocarcinoma by protein biochip technology. Cancer Res. 2002;62:1868-75